1.题目：Anovelperoralcholedochoscopewasusedtoremoveaproximaldisplacedstent-ston
ecomplex.
作者：Li,Yaoting;Yu,Tingting;He,Hongfei;......Zhang,Lichao;
通讯作者：通讯作者：张立超科室：普外九科
期刊：ENDOSCOPY.2023-12-01;55(S01):E608-E610.
文献类型：EditorialMaterial
影响因子：9.3(2022)中科院分区：1区
PMID：37040885
WOS:000969077300004
2.题目：SF3B4promotesTwist1expressionandclearcellrenalcellcarcinomaprogressionby
facilitatingtheexportofKLF16mRNAfromthenucleustothecytoplasm.
作者：Yang,Zhan;Wang,Ya-Xuan;Wen,Jin-Kun;......Qu,Chang-Bao;
通讯作者：瞿长宝科室：泌尿外科
期刊：CellDeathDis.2023-01-13;14(1):26.
影响因子：9(2022);中科院分区：2区
PMID：36639679
WOS:000989313600005
摘要：Splicingfactor3Bsubunit4(SF3B4)playsimportantfunctionalrolesnotonlyinpre-mR
NAsplicing,butalsointheregulationoftranscription,translation,andcellsignaling,anditsd
ysregulationcontributestovariousdiseasesincludingNagersyndromeandtumorigenesis.Ho
wever,theroleofSF3B4andunderlyingmechanismsinclearcellrenalcellcarcinoma(ccRCC)
remainobscure.Inthepresentstudy,wefoundthattheexpressionofSF3B4wassignificantly
elevatedinccRCCtissuesandnegativelycorrelatedwiththeoverallsurvivalofccRCCpatients
.UpregulationofSF3B4promotesmigrationandinvasionofccRCCcellsinvitroandinvivo.T
hepromotingeffectofSF3B4oncellmigrationandinvasionismediatedbyTwist1,akeytran
scriptionfactortomediateEMT.Interestingly,SF3B4,acomponentofthepre-mRNAspliceoso
me,isabletopromoteKLF16expressionbyfacilitatingthetransportofKLF16mRNAintothe
cytoplasm.Mechanistically,SF3B4promotestheexportofKLF16mRNAfromthenucleusto
thecytoplasmandthusenhancesKLF16expression,andinturnelevatedKLF16directlybinds
totheTwist1promotertoactivateitstranscription,leadingtoEMTandccRCCprogression.
OurfindingsprovideevidencethattheSF3B4-KLF16-Twist1axisplaysimportantfunctionalro
lesinthedevelopmentandprogressionofccRCC,andmanipulatingthispathwaymaybeano
veltherapeutictargetforthetreatmentofccRCC.
3.标题：Associationofexposuretoperfluoroalkylsubstancesandriskofthe;acutecoronarysy
ndrome:Acase-controlstudyinShijiazhuangHebei;Province
作者：Li,Haoran#;Chen,Jinbo;Lu,Jingchao;Yang,Jing;Tan,Zhenzhen;Li,Longfei;Xiao,Fang;
An,Ziwen;Ma,Chaoying;Liu,Yi;Wang,Lei;Zhang,Xiaoguang;Guo,Huicai*;
第一作者：李浩然科室：药学部
期刊：CHEMOSPHERE2023FEB;313卷
文献类型：Article
影响因子:8.8(2022)；中科院分区：2区
PMID:36495974
WOS:000904121100004
摘要：Exposurestoperfluoroalkylsubstances(PFAS)havebeenreportedtoincreasetherisk
ofatherosclerosis.Therefore,PFASexposuremaybelinkedtotheriskofacutecoronarysyndr
ome(ACS),butthisassociationremainsuncertain.Theobjectiveofthepresentstudywastoin
vestigatetheassociationbetweenPFASexposureandACSriskthroughacase-controlstudy.
Thestudyincluded355newlydiagnosedACScasesand355controlsmatchedbyage(within
5years)andsex.TwelvePFASweremeasuredinplasmabyultra-high-performanceliquidchr
omatography-tandemmassspectrometry.Theconditionallogisticregressionmodelswereper
formedtoinvestigatetheassociationbetweenthesingleandmultiplePFASandACSrisk.Furt
hermore,weinvestigatedtheassociationofPFASmixtureexposurewithACSriskusingaquan
tile-basedg-computation(qgcomp)approach.Amediatingeffectmodelwasusedtoassess
themediatingeffectofplateletindicesontheassociationbetweenPFASandACSrisk.Theres
ultsshowedthatperfluorooctanoicacid(PFOA)andperfluorooctanesulfonicacid(PFOS)were
significantlypositivelyassociatedwithACSriskinthemultiple-PFASmodel2,andthiseffect
wasnotsignificantinfemales.Theoddsratios(95%confidenceintervals)forPFAS(z-scorePF
AS)andACSriskwere1.51(1.07,2.15)forPFOAand1.77(1.15,2.72)forPFOS.Thedose-resp
onserelationshipsrevealedanincreasingtrendforACSriskwithPFOAandPFOSanddecreasi
ngtrendforperfluorohexanesulfonicacid(PFHxS)andperfluorodecanoicacid(PFDA).There
wasnosignificantcorrelationbetweenPFASmixtureexposureandACSrisk.Analysisofmedia
tionindicatedthatplateletcountmediatedtherelationshipbetweenPFOSandACSrisk.Our
studysuggeststhathigherlevelsofPFOAandPFOS,andlowerlevelsofPFHxSandPFDAmay
increasetheriskofACS.However,thereportednegativeassociationsshouldnotbeconsidere
dasprotective,anduncertainunresolvedconfoundingmaycontributetothisresult.
4.标题：N-dopedcore-shellmesoporouscarbonspheresembeddedbyNinanoparticlesfor
CO2electroreduction
作者：Du,Juan#;Lin,Qin-Yan;Zhang,Jian-Qi;Hou,Sen-Lin*;Chen,Ai-Bing*;