中华口腔医学会—登士柏口腔医学生研究论文英文壁报比赛
亲爱的口腔医学院校师生们：
定于2013年8月17日上午在上海召开“中华口腔医学会第15次全国口腔医学学术会议
（2013年会）”期间举办“中华口腔医学会——登士柏口腔医学生研究论文英文壁报比赛”。
今年比赛投稿采取各院校推荐或学生自愿发送电子邮件方式（投稿要求见后），参加预赛。
经评审专家组网上投票后，推选出前12名优胜者参加决赛。
12名参加决赛者需赴上海参加在中华口腔医学会第15次全国口腔医学学术会议上举办的
“中华口腔医学会—登士柏口腔医学生研究论文英文壁报比赛”决赛及颁奖仪式，届时不到者
将视为自动放弃评奖资格。
前100名优秀论文获得者可获得在第15次全国口腔医学学术会议上展出壁报的资格。
决赛设一等奖1名、二等奖3名、三等奖8名。一等奖获得者将由登士柏公司支持参加一
次国际口腔医学学术会议的经费。二等奖获得者将获得1000元奖学金，三等奖获得者将获得
500元奖学金。12名决赛选手的注册费和住宿费由登士柏公司支持。
参加比赛人员须为中国大陆口腔医学院校的七年制、八年制在校学生。
投稿截止日期：2013年6月30日
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稿件请发至：firstgccd@gmail.com，并标明“登士柏口腔医学生研究论文英文壁报比赛”
投稿
联系人：邓媛媛，联系方式；010-82195542
中华口腔医学会
2013年5月
2013年登士柏英文壁报比赛摘要提交的补充说明：
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现场比赛评分标准
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Abstract1
ActivityofAntimicrobialPeptideMimeticsAgainstCandida
R.YamarthyandG.Diamond
Objectives:Oralcandidiasis,aninfectionmainlycausedbythefungusCandidaalbicans,isanincreasingprobleminAIDSandotherimmuno-compromisingdiseases.Inthelastfewyears,antimicrobialpeptideshaveshownpromiseaseffectiveantifungaltreatments.Asthesepeptidesareexpensivetoproduce,Polymedix,Inc.,hasdevelopedasetofinexpensivecompoundsthatmimicthestructureofantimicrobialpeptides.ThegoalofthisinvestigationistoexaminetheactivityofantimicrobialpeptidemimeticstodevelopnoveltherapiesagainstCandidalinfections.
Methods:Twodifferentpeptidemimeticsweretested,PMX30016andmPE.Thesecompoundsweretestedtodeterminekineticsofkilling,minimalfungicidalconcentration(MFC),viabilityofcandidainadenturebiofilmusinganXTTassay,andsynergywithchlorohexidineandItraconazole.
Results:TheMFCsofmPEandPMX30016againstC.albicansweredeterminedtobe2μg/mLand0.25μg/mL,respectively.OtherCandidalspecieshadMFC’srangingfrom0.25to1μg/mL.TherewaspotentsynergybetweenbothcompoundsandItraconazole.KineticsofkillingexperimentsshowedthatC.albicansblastoconidiawereeliminatedcompletelywithin20minutesatanmPEdoseequivalenttofivetimestheMIC.XTTstudiesshowedthatthemetabolicactivityofC.albicansdecreasedastheconcentrationofPMX30016increased.
Conclusion:Peptide-mimeticscanformthebasisforthedevelopmentofnoveltherapiesagainstcandidalinfections.
Abstract2
Comparingsuturestrengthsforclinicalapplications-AnovelIn-vitrostudy
Background:Toachieveagoodhealingofthesurgicalsite,flapsshouldbeapproximatedandheldinplacebysutures.Strengthanddurabilityofsuturesarecriticaltosuccessfulhealing.Themostcommonlyusedabsorbablesuturesindentistryarechromicgutandpolyglactin(PGN).Anewerformoffastabsorbingpolyglactin(PGNFA)hasbeenintroducedinthemarketwithclaimsofsimilarstrengthandfasterabsorptioncomparedtoregularPGN.Thegoalofthisstudywastoassesstensilestrengthofthesethreesuturematerialskeptinasimulatedoralenvironmentovertimetodeterminewhichisbestforclinicalapplications.
Methods:Atotalof252samplesconsistingoftwodifferentgaugesofeachsuturematerialmadeupthesamplesize.Eachsamplewastiedandpre-tensionedto10.2
Newtonsandplacedinasimulatedoralenvironment.Samplesweretestedatspecified
timepointsrangingupto14days.Amicro-tensilestrengthtesterwasusedwithalinear
loadof0.04mm/sec.Resultswererecordedandtabulatedforstatisticalanalysis.Light
microscopywasusedtoanalyzethenatureoffailurewhethershreddedorstraight
severance.
ResultsandConclusions:PGNshowedthegreatestinitialtensilestrengthyetsteadily
loststrength.Chromicgutshowedthegreateststabilityofstrengthoverthetwoweeks.
PGNFAwastheweakestofallmaterialstestedandwascompletelyabsorbedin10days.
PGNFAisnotagoodmaterialfordentalsurgicalapplicationsrequiringalongerhealing
time.
Abstract3
ComparisonoftheEffectofHemostaticAgentsonCollagenInduced
PlateletAggregation
AkindekoD.Obebe,Classof2009,KornbergSchoolofDentistry,TempleUniversity
Objectives:Hemostasissubsequenttotoothextractionconsistsofcontractionofblood
vessels,plateletaggegationandplugformation,coagulationandclotformation.The
purposeofthisresearchistocomparetheeffectofvariouscommercialhemostaticagent
ontheplateletaggregationphaseofhemostasis.
Methods:Thefollowingcommercialhemostaticagentsweregroundintosmallfibers
andsuspendedataconcentrationof1mg/ml:Collaplug,Bloodstop,Surgicel,Gelfoam,
Surgifoam,Quick-clot.Hemcondentaldressingwassolubilizedat1mg/ml.Plateletrich
plasma(PRP)waspreparedfromanticoagualtedwholeblood.Forplateletaggregation
assays,PRP(108platelets/ml,450μl)wereactivatedwitheithercollagen(1mg/ml10μl),
orcollagenmixedwithhemostaticagent(eachat1mg/ml).Theeffectofeachagenton
collageninduceplateletaggregationwasmeasuredonaplateletaggregometer.
Results:Collaplug,HemconandQuick-clotenhancecollageninducedaggregationby
50%,20%,and12%respectively.Bloodstop,Surgicel,Gelfoamdidnoteffectcollagen
inducedplateletaggregation.
Conclusion:Althoughallofthecommercialproductsareknowntobeeffectiveaidsin
achievinghemostasis,onlyCollaplug,Hemcon,andQuick-clotenhancetheplatelet
aggregationphaseofhemostasis.
Abstract4
EffectofAdhesiveSystemandCompositeTypeonDentinBonds
ToddWalker,NeilJessop,GerardKugel,PaulStark.
Objective:
Toevaluatetheeffectofdifferentadhesivesystemsandcompositescombinationson
dentinalbondstrength.
Methods:
Thebondstrengthof7self-etchingand5total-etchingadhesivesystems(PeakLC/Peak
SE,PeakLC/UltraEtch,ClearFilSEBond,ClearFilS3,OptiBondAIO,XenoIV,
Prompt,AllBond3,PQ1/UltraEtch,OptiBondSolo,P&BNT,SingleBond,OneStep)
and8compositematerialcombinations(Z100,FilTechSupreme,Vit-L-Escence,
AmelogenPlus,Premise,Opalis,EsthetX,FlowIT)weretestedbymeasuringtheMPa
ofadhesivetodentinusinganInstronsheartest.Extractedhumanmolarswereprepared,
sectionedw/adiamondblade,andexposeddentinwaspolishedwith600-gritabrasive
paper.Sampleswererandomlychosenandpreparedfollowinginstructionsfromeach
company’sadhesivesystemandcompositeapplicationontoa2.39mmdiameterbutton.
Specimenswereincubatedin37degreesCwaterfor24hoursbeforeMPatesting.Seven
replicateswereanalyzedforeachcombination.Generalizedlinearmodelswereutilized
totestthesecomparisons.Byperformingtheseglobaltests,theimpactofmultiple
comparisonsisnegated.
Results:
Resultsofbondstrengthwerefoundtobehighlystatisticallysignificantinrelationto
bothcompositetypeandadhesivesystems(pAmelogenPlusandZ100compositesresultedinthehighestbondingstrength.The
adhesivePeakLCdemonstratedthehighestbondingstrengthofalladhesivestested.The
highestvaluesfoundusedthecombinationofAmelogenPlusandPeakLC.TotalEtch
systemswere,onaverage,4.2MPahigherthanotheretchingproducts(p=0.003)
Conclusion:
Theseresultssuggestthat,whilebothfactorssignificantlyaffectbondingstrength,the
adhesiveisthemostimportantdeterminant.Thisisduetothemagnitudeoftherange
betweenthehighestandlowestadhesivecomparedtothehighestandlowestcomposite.
Abstract5
BMPSignalingisRequiredforDevelopmentoftheMaxillaryProcess
B.WANG,S.FOPPIANO,D.HU,andR.S.MARCUCIO
Objectives:ToassessmorphologicaleffectsofblockingBMPsignalingatdifferenttime
pointswithintheectodermormesenchymeoftheavianmaxillaryprocess.
Methods:AreplicationcompetentretrovirusencodingNoggin(RCAS-Noggin)(control
RCAS-AlkalinePhosphatase(RCAS-AP))wasinjectedintothemesenchymeoronto
surfaceectodermoftherightmaxillaryprocessofchickembryosatHamburger-Hamiltonstage20(HH20)orHH24.EmbryosinfectedatHH20wereharvestedatHH24,HH28,HH32,andHH39.EmbryosinfectedatHH24wereharvestedatHH32,andHH39.
Results:InfectionoftheectodermwithRCAS-NogginatHH20(n=12/13)resultedinnoaberrantphenotype.Similarly,controlembryosinfectedwithRCAS-APappearednormal(HH20n=28/28).InfectionwithRCAS-NoggininthemesenchymeatHH20,resultedinseveremalformationsatHH39(n=3/3).Controlembryosshowednormalphenotype(n=1).Toelucidatethemechanism(s)underlyingtheaberrantphenotype,embryoswereexaminedatearliertimepoints.FacialprimordiaappearedunaffectedatHH24(n=7/7),andshowedaminorphenotypeatHH28(n=3/4).InfectionofthemesenchymeatHH24resultedinasimilar,butlessseverephenotypeat~HH39.
Conclusions:BlockadeofBMPsignalingintheectodermdoesnotresultinabnormalphenotype.InfectionofthemesenchymeofthemaxillaryprocesswithRCAS-Nogginresultsinseverefacialdysmorphologies.
Thesemalformationslikelyoccurprimarilyasaresultofdisruptedskeletogenesis.TimingofBMPssignalingblockadeaffectstheseverityofphenotype.
Support:T32DE07306-12,1R01DE018234-01
Abstract6
CharacterizationofaNovelAssayforOrofacialHyperalgesiaandAllodynia
SusanPutthoff,JillFehrenbacherPhD,MichaelHenryDDS,PhD,KennethHargreavesDDS,PhD
decreaseinfeedingtimewasevaluatedasanincreaseinnociception.Feedingdurationwasseentodecreasewithincreasingthermalandmechanicalstimuli.Thisbehavioralmodelwillbeausefulindexofanimalnociceptionandpossibletherapeuticsintheorofacialregion.ThisworkwassupportedbyNIDCRgrantDE14318forCOSTAR.
Abstract7
EffectsofGenderandPeriapicalInflammationonRatAdiposeTissue
RitterSA*,SandiferLC,BainJL,CaskeyCP,BaliusKE,NaftelJP,JohnsonRB
Objective:Theobjectiveofthisstudywastocomparetheserumandomentumconcentrationsofleptinandinterleukin(IL)-6betweenfemaleandmaleratswithperiapicaltoothabscesses.
Methods:48Sprague-Dawleyratswerestudied.Theyweredividedintotwogroups:thosewithexperimentally-inducedperiapicalabscessesandsham-operatedcontrols.Tocreatetheabscesses,thepulpsofthefirstandsecondmaxillarymolarteethwereexposedusinga?roundbur.24dayslater,serum,andthegreateromentumwerecollectedandimmediatelyfrozen.ThetissuesamplesweregroundinPBScontainingaproteaseinhibitor(10mgtissue/mlPBS/proteaseinhibitor).Thetotalproteincontentoftheserumandtissuesampleswasdeterminedusingabicinchoinicacidproteinassay;thetissueandserumconcentrationsofIL-6andleptinweredeterminedbyELISA.DatawereexpressedaspgIL-6orleptin/mgprotein.Theoutcomevariableswerecomparedbyfactorialanalysisofvarianceandapost-hocTukeytest.
Results:MaleswithperiapicalabscesseshadsignificantlygreaterserumIL-6andgreateromentumconcentrations(pConclusion:MaleratswithperiapicalabscesseshadagreateracutephaseresponsetoperiapicalinflammationthanfemalesandgreateraccumulationofIL-6withinthegreateromentum.Thus,maleswithtoothabscessesmaybeatgreaterriskforobesity-relatedandcardiovasculardiseasesthanfemaleswithabscessedteeth.