帕金森病的基础和临床研究,长期从事帕金森病脑功能显像等生物学标志物、早期(运动前期)帕金森病诊断和药物治疗、帕金森病病因及线粒体功能障碍机制、脑深部电刺激治疗、帕金森病慢病管理等方向的临床和研究工作。
教育经历
国外培训经历:美国匹兹堡大学神经科博士后,2006-2008年
工作经历
复旦大学附属华山医院神经内科,1999-至今
美国匹兹堡大学神经科博士后,2006-2008年
学术兼职
国家神经系统疾病临床医学研究中心专家组委员、中华医学会神经病学分会青年委员、中华医学会神经病学分会运动障碍病组委员、中华医学会老年病学学会神经病学组委员、上海医学会神经内科专业委员会委员、上海医学会神经内科分会帕金森病及运动障碍专业组副组长、上海医学会中西医结合分会常委、上海市神经内科质控中心秘书。AnnalsofTranslationalMedicine(ATM)、复旦大学学报(医学)、中国临床神经科学杂志等杂志编委。
获奖情况
2005年入选「上海市优秀青年医学人才培养计划」。
2009年复旦大学十大医务青年提名奖。
2010年上海市「浦江人才」(A类)。
2010年复旦大学优秀授课教师
2013年上海市卫生系统优秀学科带头人。
主要论文
GeJJ,WuP,PengSC,YuH,ZhangHW,GuanYH,EidelbergD,ZuoCT,MaYL*,WangJ*.Assessingcerebralglucosemetabolisminpatientswithidiopathicrapideyemovementsleepbehaviordisorder.JCerebBloodFlowMetab.2015.Epubonline.
HeQ,KoprichJB,WangY,YuWB,XiaoBG,BrotchieMJ*,WangJ*.TreatmentwithTrehalosePreventsBehavioralandNeurochemicalDeficitsProducedinanAAVα-SynucleinRatModelofParkinson’sDisease.MolNeurobiol,2015,epubonline.
LiuFT,ChenY,YangYJ,YangL,YuM,ZhaoJ,WuJJ,HuangF,LiuW,DingZT*,WangJ*.Involvementofmortalin/GRP75/mthsp70inthemitochondrialimpairmentsinducedbyA53Tmutantα-synuclein.BrainRes,2015.1604:52-61.
HeQ,WangY,LinW,ZhangQ,ZhaoJ,LiuFT,TangYL,XiaoBG,WangJ*:TrehaloseAlleviatesPC12NeuronalDeathMediatedbyLipopolysaccharide-StimulatedBV-2CellsviaInhibitingNuclearTranscriptionFactorNF-kappaBandAP-1Activation.NeurotoxRes2014.26(4):430-9
WuP,YuH,PengS,DauvilliersY,WangJ,GeJ,ZhangH,EidelbergD,MaY,ZuoC:Consistentabnormalitiesinmetabolicnetworkactivityinidiopathicrapideyemovementsleepbehaviourdisorder.Brain2014.137:3122-8.
HeQ,YuW,WuJ,ChenC,LouZ,ZhangQ,ZhaoJ,WangJ*,XiaoB*.IntranasalLPS-mediatedParkinson’smodelchallengesthepathogenesisofnasalcavityandenvironmentaltoxins.PLOSONE.2013,8(11):e78418(*co-correspondingauthor)
WangHY,GuZ,CaoC,WangJ*,LongYT*.AnalysisofaSinglealpha-SynucleinFibrillationbytheInteractionwithaProteinNanopore.AnalChem2013.85:8254-8261.(*co-correspondingauthor)
JiangT,YuWB,YaoT,ZhiXL,PanLF,WangJ*,ZhouP*.Trehaloseinhibitswild-typea-synucleinfibrillationandoverexpressionandprotectsagainsttheproteinneurotoxicityintransducedPC12cells.RSCAdvances,2013.3:9500-9508(*Co-correspondingAuthor)
WangJ,HoekstraJG,ZuoC,ZhangJ.BiomarkersofParkinson'sdisease:currentstatusandfutureperspectives.DrugDiscovToday2013,18:155-162.
LanDM,LiuFT,ZhaoJ,ChenYan,WuJJ,DingZT,YueZY,RenHM,JiangYP,WangJ*.EffectoftrehaloseonPC12cellsoverexpressingwild-typeorA53Tmutantα-synuclein.NeurochemRes.2012;37:2025-2032.(*CorrespondingAuthor)
YuWB,JiangT,LanDM,LuJH,YueZY,WangJ*,ZhouP:TrehaloseinhibitsfibrillationofA53Tmutantalpha-synucleinanddisaggregatesexistingfibrils.ArchBiochemBiophy2012,523(2):144-150.(*Correspondingauthor)
WuJJ,YuWB,ChenY,SuYR,DingZT,RenHM,JiangYP,WangJ*.IntrastriatalTransplantationofGDNF-engineeredBMSCsanditsneuroprotectioninLactacystin-inducedParkinsonianRatModel.NeurochemRes,2010.35:495-502.(*Correspondingauthor)
WangJ,MaY,HuangZ,SunB,GuanY,ZuoC.ModulationofMetabolicBrainFunctionbyBilateralSubthalamicNucleusStimulationintheTreatmentofParkinson’sdisease.JNeurol,2010,257(1):72-78.
WangJ,LouH,PedersenCJ,SmithAD,PerezRG.14-3-3zetacontributestotyrosinehydroxylaseactivityinMN9Dcells:Localizationofdopamineregulatoryproteinstomitochondria.JBiolChem2009,284:14011-14019.
WangJ,ZuoCT,JiangYP,GuanYH,ChenZP,XiangJD,etal.18F-FP-CITPETimagingandSPManalysisofdopaminetransportersinParkinson’sdiseaseinvariousHoenh&Yahrstages.JNeurol,2007.254:185-190.
SuYR,WangJ*,WuJJ,ChenY,JiangYP.OverexpressionofLentivirus-mediatedGDNFinBoneMarrowStromalCellsandItsNeuroprotectiontoLactacystin-inducedDamageofPC12cells.NeurosciBull,2007,23:67-74.(*Correspondingauthor)
WangJ,JiangYP,LiuXD,ChenZP,YangLQ,LiuCJ.Tc-TRODAT-1SPECTstudyinearlyParkinson'sdiseaseandessentialtremor.ActaNeurolScand2005;112(6):380-385.